Coagulation support: fresh frozen plasma versus clotting factor concentrate

Transfusion in trauma: thromboelastometry-guided coagulation factor concentrate-based therapy versus standard fresh frozen plasma-based therapy

INTRODUCTION Thromboelastometry (TEM)-guided haemostatic therapy with fibrinogen concentrate and prothrombin complex concentrate (PCC) in trauma patients may reduce the need for transfusion of red blood cells (RBC) or platelet concentrate, compared with fresh frozen plasma (FFP)-based haemostatic therapy. METHODS This retrospective analysis compared patients from the Salzburg Trauma Centre (S...

Technical method. Fresh frozen cryosupernatant in place of fresh frozen plasma for broad spectrum coagulation factor replacement.

Inappropriateness of fresh frozen plasma for abnormal coagulation tests.

BACKGROUND There is increasing evidence to suggest that the use of fresh frozen plasma (FFP) as a prophylaxis to bleeding is ineffective. However, a high proportion of FFP transfusions still occur in non-bleeding patients despite the high risk of adverse events. The aim of the study was to assess compliance with current prophylactic FFP guidelines at a large tertiary centre. METHODS Data were...

Coagulation Factors Level in Fresh Frozen Plasma in Rwanda.

UNLABELLED Objectives: To determine the level of coagulation factors and inherited inhibitors in Fresh Frozen Plasma (FFP) and to evaluate Prothrombin Time and activated partial thrombin time in fresh frozen plasma. DESIGN Cross-sectional study. SETTING Jomo Kenyatta University of Agriculture and Technology in Medical Laboratory Sciences. SUBJECTS Eighteen blood bags collected from volunt...

Coagulation and Transfusion Medicine / RATIONAL FRESH FROZEN PLASMA TRANSFUSION Toward Rational Fresh Frozen Plasma Transfusion The Effect of Plasma Transfusion on Coagulation Test Results

Numerous published guidelines encourage appropriate use of fresh frozen plasma (FFP). However, adherence is documented as poor. Therefore, we sought to determine the laboratory effect of FFP administration to patients with an international normalized ratio (INR) less than 1.6 (prothrombin time <1.6 times normal). We found minimally prolonged INRs decreased with treatment of the underlying disea...